lodination of Thyroliberin by Use of lodogen

نویسندگان

  • Stephen A. Butler
  • Robert W. Lam
  • Delbert A. Fisher
چکیده

In this method of labeling thyroliberin for radioimmunoassay, 1,3,4,6-tetrachloro-3a,6a-diphenylglycoluril (lodogert#{174}) is usedas oxidant. By cation-exchange chromatography and in response to antibody, thyroliberin so labeled behaved similarly to that produced by the conventional Chloramine-T method. Major advantages of the lodogen method are its reliability, simplicity, and higher yield of stable RIA label in its most convenient (diiodinated) form.

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تاریخ انتشار 2004